Jocelynn R. Pearl

The paper identifies altered huntingtin-chromatin interactions in HD mouse models, linking them to transcriptional and epigenetic changes in striatal tissue.

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

This study demonstrates precise control of gene expression levels by targeting the KRAB repressor domain in human cells.

The paper constructs a brain-specific transcriptional regulatory network model to identify core transcription factors involved in psychiatric and neurodegenerative diseases.

The paper builds genome-scale transcriptional regulatory networks for mouse and human striatum, identifying SMAD3 as a key regulator in Huntington’s disease.