Matthew S. Wilken

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

X-Cell predicts causal perturbation responses across diverse cellular contexts using a diffusion language model trained on a large CRISPRi Perturb-seq dataset.

Large-scale discovery of potent, compact and lineage specific enhancers for gene therapy vectors

The paper identifies potent, compact, and lineage-specific enhancers for gene therapy vectors using epigenomic data and validates their efficacy in correcting a thalassemia phenotype.

Quantitative dialing of gene expression via precision targeting of KRAB repressor

This study demonstrates precise control of gene expression levels by targeting the KRAB repressor domain in human cells.

Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative Capacity

The paper identifies loss of neurogenic gene expression and motif accessibility in mature Muller glia that limits their regenerative capacity.

STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Muller glia in adult mouse retina.

This study shows that STAT pathway activation limits Ascl1-mediated chromatin remodeling in Muller glia, reducing their ability to regenerate neurons in the adult mouse retina.