Simon Huw Reed

This study demonstrates that inducible ER alpha in normal breast epithelial cells induces DNA damage and identifies gene expression changes and DSBs similar to breast cancer cells.

This study identifies BAZ2 chromatin remodelers as suppressors of G4 DNA structures and shows that their depletion increases G4 formation and genomic instability.

The paper introduces INDUCE-seq, a method to accurately detect both endogenous and induced DNA double strand breaks, overcoming limitations of existing methods.

The paper identifies chromatin domains and shows how GG-NER initiates repair by remodeling nucleosomes at gene promoter boundaries.

The paper examines how DNA repair rates vary across the genome in budding yeast and shows that GG-NER is organized into chromatin domains that promote efficient repair.