Shuvro Prokash Nandi

Human cancer genomes harbor the mutational signature of tobacco-specific nitrosamines NNN and NNK

The paper identifies mutational signatures in cancer genomes caused by tobacco-specific nitrosamines NNN and NNK, showing their unique contribution to specific cancer types.

Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression

This study uses multi-omics profiling to show that house dust mite exposure accelerates lung tumor growth through immune-mediated mechanisms by altering the tumor microenvironment.

The DREAM complex links somatic mutation, lifespan, and disease

This study shows that DREAM complex activity influences somatic mutation burden, lifespan, and age-related disease, with reduced activity linked to longer lifespan and lower disease risk.

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic Mutations

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

Improved Mutation Detection in Duplex Sequencing Data with Sample-Specific Error Profiles

DupCaller improves mutation detection in duplex sequencing by using sample-specific error profiles and a strand-aware model, increasing sensitivity across various samples and conditions.

Carcinogen-induced DNA adducts amplify APOBEC mutagenesis through nucleotide excision repair

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

Nucleosome remodelling at origins of Global Genome-Nucleotide Excision Repair occurs at the boundaries of higher-order chromatin structure

The paper identifies chromatin domains and shows how GG-NER initiates repair by remodeling nucleosomes at gene promoter boundaries.