Author

Vibeke Kruse

Novo Nordisk FoundationORCID 0000-0002-4724-9028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1 Organism:yeast· 1

Frequent Co-Authors

Karl Alex HediniD· 2 shared Morten Otto Alexander SommeriD· 2 shared Ruben Vazquez-UribeiD· 2 shared Fredrik BäckhediD· 1 shared Hongbin ZhangiD· 1 shared Thomas Uwe GreineriD· 1 shared Vanessa Emily ReesiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersSynthetic Biology

Karl Alex HedinORCID

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2 papers

Recent·Most cited

Biocontainment strategies for in vivo applications of Saccharomyces boulardii

Karl Alex Hedin, Vibeke Kruse, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer

This paper develops a biocontainment strategy for Saccharomyces boulardii by knocking out THI6 and BTS1, resulting in auxotrophy and cold sensitivity, which limits its growth outside the host.

Frontiers in Bioengineering and Biotechnology · Feb 20, 2023Peer-reviewedSynthetic Biology

Oral delivery of GLP-1R agonist by an engineered probiotic yeast strain has anti-obesity effects in mice

Karl Alex Hedin, Hongbin Zhang, Vibeke Kruse, Vanessa Emily Rees, Fredrik Bäckhed, Thomas Uwe Greiner, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer

This study engineers a probiotic yeast to produce a GLP-1R agonist in the gut, reducing obesity in mice through improved metabolism and weight loss.

bioRxiv · Dec 21, 2022 · PreprintSynthetic Biology