Karl Alex Hedin

This study shows that Saccharomyces boulardii reduces obesity-related inflammation and weight gain in mice through changes in gut microbiota and host metabolism.

This paper compares genomic and phenotypic traits of Saccharomyces boulardii and Saccharomyces cerevisiae strains to identify functional differences relevant to probiotic efficacy.

This paper develops a biocontainment strategy for Saccharomyces boulardii by knocking out THI6 and BTS1, resulting in auxotrophy and cold sensitivity, which limits its growth outside the host.

This study engineers a probiotic yeast to produce a GLP-1R agonist in the gut, reducing obesity in mice through improved metabolism and weight loss.