Fredrik Bäckhed

This study identifies sex-specific transcriptional differences in liver and visceral adipose tissue in MASLD and shows coordinated cross-tissue states.

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

This study shows that gut microbial metabolite imidazole propionate impairs endothelial function and promotes atherosclerosis in both human and animal models.

This study isolates and characterizes a novel Clostridium species, C. filamentum ETTB, which modulates the TLR5 pathway in host cells and has distinct genomic features compared to related species.

This study engineers a probiotic yeast to produce a GLP-1R agonist in the gut, reducing obesity in mice through improved metabolism and weight loss.

The paper analyzes metabolic responses to a mixed meal test in an obese cohort, linking tissue metabolism with gut microbiota changes and identifying potential biomarkers for T2DM.