Morten Otto Alexander Sommer

This study shows that Saccharomyces boulardii reduces obesity-related inflammation and weight gain in mice through changes in gut microbiota and host metabolism.

This paper compares genomic and phenotypic traits of Saccharomyces boulardii and Saccharomyces cerevisiae strains to identify functional differences relevant to probiotic efficacy.

This study engineers S. boulardii to control gene expression and gut residence time via diet-responsive systems, enabling precise therapeutic delivery in the mouse gut.

This study performs a pangenome analysis of the Lactobacillaceae family, revealing correlations between pangenome openness, transposon abundance, and species-specific genomic features.

This paper develops a biocontainment strategy for Saccharomyces boulardii by knocking out THI6 and BTS1, resulting in auxotrophy and cold sensitivity, which limits its growth outside the host.

This study engineers a probiotic yeast to produce a GLP-1R agonist in the gut, reducing obesity in mice through improved metabolism and weight loss.

The paper identifies a novel L-lysine exporter from cow gut microbiome metagenomic fragments, improving L-lysine tolerance and productivity in bacterial hosts.

The paper designs synthetic control circuits in yeast to stabilize vanillin-β-glucoside production over multiple generations, achieving higher yields in fermentation.

NetSurfP-2.0 improves prediction of protein structural features with higher accuracy and faster runtime than previous versions.