Investigation of Bile Salt Hydrolase Activity in Human Gut Bacteria Reveals Production of Conjugated Secondary Bile Acids
Lauren N. Lucas, Jillella Mallikarjun, Lea E. Cattaneo, Bhavana Gangwar, Qijun Zhang, A. P. Clay, Robert L. Kerby, David M. Stevenson, Helen E. Blackwell, Federico E. Rey, Daniel Amador‐Noguez
This study investigates BSH activity in human gut bacteria and finds that some strains can directly dehydrogenate conjugated bile acids to produce conjugated secondary bile acids, challenging the idea that deconjugation is a prerequisite for further modifications.
Nature Communications · Feb 23, 2026Peer-reviewedMicrobiology