Cell BiologybioRxivPreprint
Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies
Jun Liu, Ziyang Shen, Shin‐Young Park…·Li Chai
This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.
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