Braden Pate

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies

This paper uses iPSC-derived erythroid cells to model genetic diversity in sickle cell disease and shows they reflect heterogeneous responses to HbF-inducing therapies like hydroxyurea.

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

Investigating low frequency somatic mutations in Arabidopsis with Duplex Sequencing

The paper uses Duplex Sequencing to measure somatic mutation rates in Arabidopsis under different temperatures, finding very low mutation frequencies in wild-type plants.