Christoph Budjan

Robust axis formation requires both short-range adhesion and long-range attraction

The paper models how short-range adhesion and long-range attraction in gastruloids lead to robust axis formation, supported by experimental validation.

Discovery of A Small Molecule non-IMiD Degrader of ZBTB7A for the Treatment of β-hemoglobinopathies

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

Paraxial mesoderm organoids model development of human somites

This study generates human paraxial mesoderm organoids that form somite-like structures in vitro, enabling analysis of human spinal cord development.

In vitro characterization of the human segmentation clock

The paper identifies a human segmentation clock by showing human PSM cells exhibit Notch and YAP-dependent oscillations of HES7 with a 5-hour period.