Author

Alexine Simone de Wit

University of GroningenORCID 0000-0002-4753-6748Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Frans BianchiiD· 1 shared Geert van den BogaartiD· 1 shared Harry M. WarneriD· 1 shared Huang Huang· 1 shared Martijn VerdoesiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

Frans BianchiORCID

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1 paper

Recent·Most cited

Inhibition of SHP-1 /2 blocks antigen cross-presentation by human macrophages and dendritic cells

Alexine Simone de Wit, Harry M. Warner, Huang Huang, Martijn Verdoes, Geert van den Bogaart, Frans Bianchi

This study shows that inhibiting SHP-1/2 reduces antigen cross-presentation by macrophages and dendritic cells, potentially limiting the effectiveness of PD-1 checkpoint therapy.

bioRxiv · Oct 21, 2025 · PreprintImmunology