Harry M. Warner

This study shows CD82 reduces CADM1 oligomer formation by interacting with its extracellular domains, affecting transmembrane helix spacing and disrupting cell adhesion.

This study shows that inhibiting SHP-1/2 reduces antigen cross-presentation by macrophages and dendritic cells, potentially limiting the effectiveness of PD-1 checkpoint therapy.

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.