Paula Desplats

This study uses spatial transcriptomics to show that Alzheimer's disease disrupts circadian rhythms in specific brain regions before amyloid plaques form in a mouse model.

The paper improves rRNA depletion for mouse cecal metatranscriptome analysis by designing probes based on sequence abundance rather than taxonomy, increasing mRNA reads and reducing bias.

The paper identifies a topographic organization in the posterolateral cortical amygdala (plCoA) that controls innate olfactory attraction and aversion through distinct cell types and projections.

Time-restricted feeding reduces amyloid deposition, improves behavior, and normalizes gene expression in a mouse model of Alzheimer's disease.