Author

Karima Mokhtari

Centre National de la Recherche ScientifiqueORCID 0000-0002-4777-7584Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Agustí AlentorniD· 3 shared Ahmed IdbaïhiD· 2 shared Bertrand MathoniD· 2 shared Franck BielleiD· 2 shared Isaias Hernández-VerdíniD· 2 shared Khê Hoang‐XuaniD· 2 shared Marc SansoniD· 2 shared Mehdi TouatiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBioinformatics

Agustí AlentornORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintSep 3, 2026

Morphologic intratumoral heterogeneity from routine whole-slide histopathology is prognostic for survival in primary central nervous system lymphoma: development in the LOC Network and international external validation

Lucas Rincón de la Rosa, Noemie Barillot, Isaias Hernández-Verdín…·Agustí Alentorn

The paper develops and validates a prognostic model using morphologic intratumoral heterogeneity from histopathology slides to predict survival in primary central nervous system lymphoma.

DOI 10.64898/2026.08.31.748241

humanimaging

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Cancer BiologybioRxivPreprintAug 23, 2024

Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas

Alice Laurenge, Pietro Pugliese, Sarah Scuderi…·Luis Jaime Castro‐Vega

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

3 citations

humanDNA methylation

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BioinformaticsbioRxivPreprintJun 26, 2021

Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response

Isaias Hernández-Verdín, Kadir Caner Akdemir, Daniele Ramazzotti…·Agustí Alentorn

The paper analyzes AID-related mutations across cancers and finds they are associated with better outcomes in ICI-treated patients and contribute to immunogenic neoepitopes.

DOI 10.1101/2021.06.26.447715

humanwhole-genome sequencing

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