Mehdi Touat

RIG-I RNA agonist activates immunostimulatory macrophages to enhance checkpoint immunotherapy for glioblastoma

The paper shows that activating RIG-I in macrophages enhances immunotherapy for glioblastoma by repolarizing tumor-associated macrophages and boosting anti-tumor immune responses.

A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

Oncometabolite-driven enhancer hypermethylation promotes a hyporesponsive microglial state in IDH-mutant gliomas

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

Pan-cancer landscape of AID-related mutations, composite mutations and its potential role in the ICI response

The paper analyzes AID-related mutations across cancers and finds they are associated with better outcomes in ICI-treated patients and contribute to immunogenic neoepitopes.