Franck Bielle

This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.

This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.

The paper identifies a prognostic infiltration zone in glioblastoma using histology and spatial transcriptomic integration, revealing specific cell composition associated with long-term survival.

This study shows that oncometabolite D-2HG drives enhancer hypermethylation in IDH-mutant gliomas, leading to hyporesponsive microglia and reduced immune reactivity.

The paper analyzes AID-related mutations across cancers and finds they are associated with better outcomes in ICI-treated patients and contribute to immunogenic neoepitopes.