Chen Mozes

Chemoproteomic Characterization of GPX4 Covalent Ligands and Targeted Degradation

The paper characterizes a covalent GPX4 inhibitor and develops degraders, expanding tools for GPX4 targeting.

Covalent Reprogramming of Kinase Binders to Modulate Protein Homeostasis

The paper shows that adding electrophilic groups to kinase ligands can stabilize or degrade proteins, demonstrating a new way to modulate protein homeostasis through covalent interactions.