BiochemistrybioRxivPreprint
Covalent Reprogramming of Kinase Binders to Modulate Protein Homeostasis
Chen Mozes, Xiao‐Kang Jin, Miguel A. Lorenzo Campos…·Xiaoyu Zhang
The paper shows that adding electrophilic groups to kinase ligands can stabilize or degrade proteins, demonstrating a new way to modulate protein homeostasis through covalent interactions.
DOI 10.1101/2025.11.30.691461