Thomas Lenz

The paper shows that the PPIP5K enzyme Asp1 produces opposite effects on fungal morphology and actin organization in different species, depending on the host cellular environment.

This study shows that canonical autophagy remains inactive in iPSCs and NPCs under DNA damage, despite a functional autophagy machinery and responsive DNA damage response.

This study shows HDAC6 inhibition enhances anti-tumoral immune responses and chemosensitivity in myeloid leukemia cells by upregulating RNase T2 and improving chromatin accessibility.

This study develops a bipyrimidineamide-based α-helix mimetic compound, VWK603, which effectively targets MDM2 in TNBC cells with lower toxicity than Nutlin-3a.