Jimena Monzón‐Sandoval

Changes in neural progenitor lineage constituent during astrocytic differentiation of human iPSCs

This study shows that astrocytes derived from LMX1A+ progenitors lose lineage composition during differentiation unless progenitors are purified, using deep single-cell RNA sequencing.

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson's disease and neuropsychiatric disorders.

The paper constructs a single-cell atlas of the Substantia nigra and identifies cell-specific gene expression patterns linked to Parkinson's disease and neuropsychiatric disorders.

Combining multi-omics and drug perturbation profiles to identify novel treatments that improve disease phenotypes in spinal muscular atrophy

This study identifies novel drug treatments for spinal muscular atrophy by integrating multi-omics data and drug perturbation profiles, showing harmine improves disease phenotypes in models.