Ana Isabel Domingos

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

This study shows that β2AR agonists enhance thermogenesis and prevent obesity by improving sympathetic neuron function in mice.

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

TopoMetry learns and evaluates the latent geometry of single-cell data, preserving structure better than standard methods and revealing hidden biological signals.