Pedro A. S. Nogueira

Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations

This study maps tryptophan metabolites across multiple tissues, sexes, and ages in mice, revealing significant variations in metabolism that could inform disease-targeted therapies.

CETP expression in females increases body metabolism under both cold exposure and thermoneutrality contributing to a leaner phenotype

This study shows CETP expression in female mice increases body metabolism under cold exposure and thermoneutrality, leading to a leaner phenotype through enhanced BAT activity and muscle metabolism.

POMC-specific knockdown of Tril reduces body adiposity and increases hypothalamic leptin responsiveness

The paper identifies Tril as a mediator of high-fat diet effects in POMC neurons, showing that its knockdown reduces adiposity and increases leptin responsiveness in the hypothalamus.