Mahesh Karnani

This paper introduces a mouse model of self-initiated restrictive feeding (SIRF) that mimics features of anorexia nervosa and identifies neural mechanisms involved in the behavior.

The paper identifies the medial prefrontal cortex as the strongest cortical input to the lateral hypothalamus, with distinct synaptic dynamics and integration patterns.

This study shows that ACC inputs to the claustrum change from excitatory to inhibitory with age, linked to parvalbumin interneuron maturation in mice.

The paper introduces the Switchmaze, an open-design device to measure motivational switching in mice, showing its utility in studying neural mechanisms of behavior.

This study shows that orexin neurons decode blood glucose dynamics to drive adaptive behavior in mice by tracking glucose gradients and generating neural adaptations.

The paper investigates connectivity within the lateral hypothalamus and finds near-zero local connectivity and absence of local oscillations, suggesting integration occurs at the single-neuron level.

This study shows orexin/hypocretin neurons rapidly control movement by integrating sensory input and initiating locomotion.