Structural basis for ACT1 oligomerization induced by IL-17 receptor hetero-tetramer
Hui Zhang, Xiao‐chen Bai, Xuewu Zhang
The paper determines the cryo-EM structure of the IL-17RA, IL-17RB, and ACT1 complex, revealing how these proteins form a hetero-tetramer to initiate immune signaling.
Nature Communications · Dec 16, 2025Peer-reviewedImmunology