Author

Theo L. Sinnige

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Adam MyszczyszyniD· 2 shared Bart SpeeiD· 2 shared Luc J. W. van der LaaniD· 2 shared Agnès JaminiD· 1 shared Anna MuenchiD· 1 shared Arif Ibrahim ArdisasmitaiD· 1 shared Ary MarseeiD· 1 shared Barbara KubíčkováiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

Adam MyszczyszynORCID

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Author profile →

3 papers

Recent·Most cited

Chemical augmentation of the validated HepaRGTM CYP enzyme induction test method Part 1: The Goliath two laboratory study

Miriam Naomi Jacobs, Barbara Kubíčková, Elodie Person, Jorke Harmen Kamstra, Nicolas J. Cabaton, Sebastian Hoffmann, Agnès Jamin, Marlène Z. Lacroix, Juliette Legler, Vesna Munić Kos, Sandra M. Nijmeijer, Theo L. Sinnige, Laurie Urien, Daniel Zalko

This paper validates the HepaRG CYP enzyme induction test method for pharmaceutical and non-pharmaceutical chemicals, showing good reproducibility for pharmaceuticals but less consistency for non-pharmaceuticals.

bioRxiv · Jun 20, 2026 · PreprintPharmacology & Toxicology

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport

Adam Myszczyszyn, Anna Muench, Vivian Lehmann, Theo L. Sinnige, Frank G. van Steenbeek, Manon Bouwmeester, Roos‐Anne Samsom, Marit Keuper-Navis, Thomas K. van der Made, Daniel Kogan, Sarah Braem, Luc J. W. van der Laan, Hossein Eslami Amirabadi, Evita van de Steeg, Rosalinde Masereeuw, Bart Spee

This paper develops a liver organoid-on-a-chip model using hollow fiber membranes to study drug metabolism and transport, showing improved hepatocyte-like maturation and functional drug processing.

Biofabrication · Mar 21, 2025Peer-reviewedPharmacology & Toxicology

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

Arif Ibrahim Ardisasmita, Indi P. Joore, N. Levy, Adam Myszczyszyn, Ary Marsee, Theo L. Sinnige, Jos P.N. Ruiter, Sacha Ferdinandusse, Oksana Y. Dudaryeva, E. Gruber, V. Daive, Riccardo Levato, Bart Spee, Monique M. A. Verstegen, Luc J. W. van der Laan, , Sabine A. Fuchs

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

bioRxiv · Oct 29, 2024 · PreprintCell Biology