Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer
Jennifer E. Kay, Joshua J. Corrigan, Lindsay B. Volk, Amanda L. Armijo, Ilana S. Nazari, Dorothea K. Torous, Svetlana L. Avlasevich, Robert G. Croy, Dushan N. Wadduwage, Stephen D. Dertinger, John M. Essigmann, Leona D. Samson, Bevin P. Engelward
This study investigates sex differences in susceptibility to NDMA-induced mutations, toxicity, and cancer in mice, finding males are more prone to cancer while Aag overexpression increases toxicity, particularly in females.
bioRxiv · May 13, 2025 · PreprintCancer Biology