Alexander M. van der Linden

KIN-29 SIK regulates stress-induced sleep through mitochondrial redox signaling

This study shows that KIN-29 regulates stress-induced sleep in C. elegans via mitochondrial ROS signaling, with ROS acting downstream of KIN-29 and upstream of the ALA neuron.

The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans

This study shows that NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans by modulating splicing events and circRNA production.

Loss of age-accumulated crh-1 circRNAs ameliorate amyloid β-induced toxicity in a C. elegans model for Alzheimers disease

The paper shows that loss of age-accumulated circ-crh-1 circRNAs reduces Aβ-induced toxicity in C. elegans, suggesting a protective role against Alzheimer's disease.

Dietary vitamin B12 regulates chemosensory receptor gene expression via the MEF2 transcription factor in Caenorhabditis elegans

The paper shows that vitamin B12 from bacteria modulates chemoreceptor gene expression in C. elegans via the MEF-2 transcription factor, affecting sensory responses to diet.

A salt-induced kinase (SIK) is required for the metabolic regulation of sleep

This study identifies KIN-29, a C. elegans SIK homolog, as essential for metabolic regulation of sleep by linking energy deficits to sleep promotion through nuclear actions in sensory neurons.

Global accumulation of circRNAs during aging in Caenorhabditis elegans

This study identifies age-related accumulation of circRNAs in C. elegans and links it to postmitotic cell composition and circRNA stability.