Pedro Miura

This study shows that NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans by modulating splicing events and circRNA production.

APALORD is an R-based tool for analyzing differential alternative polyadenylation in long-read RNA-seq data, identifying polyadenylation sites and quantifying their usage across biological conditions.

The paper uses targeted long-read sequencing to show how alternative splicing and polyadenylation are coordinated in Drosophila.

The paper identifies NOVA2 as a key regulator of circRNA biogenesis in the developing mouse brain, showing its role in enhancing circRNA levels through specific binding sites.

This paper shows that Elav regulates alternative polyadenylation and splicing of Dscam1, which is essential for axon growth in Drosophila.

The paper uses CRISPR-Cas9 to remove a long 3′ UTR isoform of Calm1 in mice, showing impaired dorsal root ganglion development.

This study identifies age-related accumulation of circRNAs in C. elegans and links it to postmitotic cell composition and circRNA stability.