Hangpeng Li

FACT safeguards promoter topology by maintaining nucleosomes and restricting chromatin factor spreading

This study shows FACT maintains promoter topology by preserving nucleosomes and preventing chromatin factor spreading into gene bodies.

Enhancers mediate euchromatin hopping at chromatin contact points

The paper shows enhancers mediate euchromatin hopping, spreading euchromatin features to distal regions through chromatin looping, redefining enhancer identification using chromatin features.

Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites

The paper identifies that SOX2 maintains chromatin accessibility at regulatory sites that drive gene expression, distinguishing them from non-activating binding sites.