Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein
Maria Zacharopoulou, Neeleema Seetaloo, James F. Ross, Amberley D. Stephens, Giuliana Fusco, Thomas M. McCoy, Wenyue Dai, Ioanna Mela, Ana Fernández‐Villegas, Anne Martel, Alexander F. Routh, Alfonso De Simone, Jonathan J. Phillips, Gabriele S. Kaminski Schierle
This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.
Journal of the American Chemical Society · Apr 10, 2025Peer-reviewedBiophysics