Substrate recognition, not sequestration, drives the engagement of an H3K9 methyltransferase in living cells
Yekaterina Fyodorova, Samuel B.W. Steen, Alexander Levashkevich, Luis A. Ortiz‐Rodríguez, Sumanth Kumar Maheshwaram, Serena Chiu, Kaushik Ragunathan, Julie S. Biteen
This study shows that Clr4's engagement with chromatin in S. pombe is driven by substrate recognition, not sequestration, through guided search behavior.
bioRxiv · Jul 3, 2026 · PreprintBiophysics