Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia
Luca J. Delfinis, Leslie M. Ogilvie, Shahrzad Khajehzadehshoushtar, Shivam Gandhi, Madison C. Garibotti, Arshdeep K. Thuhan, Kathy Matuszewska, Madison Pereira, Ronald G. Jones, Arthur J. Cheng, Thomas James Hawke, Nicholas Perry Greene, Kevin A. Murach, Jeremy A. Simpson, Jim Petrik, Christopher G. R. Perry
This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.
Molecular Metabolism · Jun 24, 2024Peer-reviewedPhysiology