Nicholas Perry Greene

This study examines age-related differences in myonuclear multi-omic responses to muscle hypertrophy in mice, identifying transcriptional, epigenetic, and regulatory mechanisms underlying age-dependent muscle plasticity.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.

This study identifies biphasic transcriptional changes in female skeletal muscle during cancer cachexia, distinct from males, with sex-specific gene expression patterns and implications for therapeutic targets.