Luca J. Delfinis

The mitochondrial-targeted antioxidant SkQ1 prevents mitochondrial-linked apoptosis but not necroptosis or skeletal muscle atrophy in ovarian cancer

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

DIfferential Branched-Chain Amino Acid Metabolism in Tissues of Tumour-Bearing Mice

This study examines how tumor burden alters branched-chain amino acid (BCAA) metabolism across multiple tissues in a cancer cachexia model, revealing tissue-specific metabolic reprogramming and potential limitations of BCAA-based therapies.

Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy

This study shows adiponectin receptor agonism prevents right ventricular fibrosis and inflammation in a mouse model of Duchenne muscular dystrophy.

Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia

This paper introduces a novel mouse model of ovarian cancer cachexia showing that muscle weakness and mitochondrial stress occur before metastasis and atrophy in specific muscles.