Author

Hongyuan Wang

University College LondonORCID 0000-0002-4907-4946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 2 Approach:machine learning (classical)· 1

Frequent Co-Authors

David GemsiD· 4 shared Marina EzcurraiD· 3 shared Aihan ZhangiD· 2 shared Ann F. Gilliat· 2 shared Carina C. KerniD· 2 shared Yuan ZhaoiD· 2 shared Alexandre BenedettoiD· 1 shared Alis Saez Allende· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersPhysiology

David GemsORCID

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4 papers

Recent·Most cited

Longevity in C. elegans Eat mutants is largely attributable to reduced bacterial infection

Hongyuan Wang, Yuan Zhao, Faria Athar, Jennifer N. Lohr, Zhou Yang, Bruce Zhang, Hannah Chapman, Ioan Marcu, Mila Penzel, David Gems

This study shows that the longevity of C. elegans Eat mutants is mostly due to reduced bacterial infection rather than dietary restriction.

bioRxiv · Jul 13, 2026 · PreprintPhysiology

A hierarchy of causes of death in senescent C. elegans

Hongyuan Wang, Carina C. Kern, Chiminh Nguyen Hong, Alis Saez Allende, Jiayi Qiao, Aihan Zhang, Yimu Fan, Marina Ezcurra, David Gems

The paper shows that in C. elegans, lifespan is limited by competing senescent pathologies, and removing one can unmask another, indicating lifespan extension may not reflect reduced aging rate.

npj Aging · Mar 3, 2026Peer-reviewedPathology

Machine learning predicts lifespan and underlying causes of death in aging C. elegans

Carina C. Kern, Petru Manescu, Matt Cuffaro, Catherine Au, Aihan Zhang, Hongyuan Wang, Ann F. Gilliat, Marina Ezcurra, David Gems

The paper uses machine learning to predict lifespan and causes of death in aging C. elegans by analyzing senescent pathology and genetic factors.

bioRxiv · Mar 20, 2024 · PreprintGenetics

Monsters in the uterus: A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

Hongyuan Wang, Yuan Zhao, Marina Ezcurra, Alexandre Benedetto, Ann F. Gilliat, Josephine E. E. U. Hellberg, Ziyu Ren, Evgeniy R. Galimov, Trin Athigapanich, Johannes Girstmair, Maximilian J. Telford, Colin T. Dolphin, Zhizhou Zhang, David Gems

The paper investigates uterine tumors in C. elegans as a senescent pathology caused by quasi-programs, showing similarities to teratomas and senescence.

npj Aging and Mechanisms of Disease · Jun 7, 2018Peer-reviewedDevelopmental Biology