Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity
Rachel K. Meade, Oyindamola O. Adefisayo, Marco Túlio Pardini Gontijo, Summer J. Harris, Charlie J. Pyle, Kaley M. Wilburn, Alwyn M. V. Ecker, Erika J. Hughes, Paloma D. Garcia, Josh Ivie, Michael L. McHenry, Penelope H. Benchek, Harriet Mayanja‐Kizza, Jadee Neff, Dennis C. Ko, , Clare M. Smith
This study identifies cathepsin Z as a susceptibility factor for tuberculosis severity in both mice and humans, showing its role in disease outcomes through genetic and cellular analyses.
PLoS Biology · Sep 9, 2025Peer-reviewedGenetics