Author

Alwyn M. V. Ecker

Duke UniversityORCID 0000-0002-1619-3885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ana Ruiz ManzanoiD· 1 shared Catherine M. SteiniD· 1 shared Charlie J. PyleiD· 1 shared Clare M. SmithiD· 1 shared David M. TobiniD· 1 shared Dennis C. KoiD· 1 shared Eric A. GalburtiD· 1 shared Erika J. HughesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Ana Ruiz ManzanoORCID

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2 papers

Recent·Most cited

MicrobiologyPLoS GeneticsPeer-reviewedFeb 12, 2026

Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis sensitivity to nitric oxide stress

Natalie R. Sontag, Ana Ruiz Manzano, Alwyn M. V. Ecker…·Shumin Tan

This study shows that STPK phosphorylation of DosR in Mtb reduces its transcriptional activity and alters its response to nitric oxide stress, highlighting a regulatory interaction between STPKs and TCSs.

1 citation

bacteria (other)DNA methylation

𝕏 PostBluesky

GeneticsPLoS BiologyPeer-reviewedSep 9, 2025

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

Rachel K. Meade, Oyindamola O. Adefisayo, Marco Túlio Pardini Gontijo…·Clare M. Smith

This study identifies cathepsin Z as a susceptibility factor for tuberculosis severity in both mice and humans, showing its role in disease outcomes through genetic and cellular analyses.

3 citations

mousehuman

𝕏 PostBluesky