Author

Erika J. Hughes

Duke UniversityORCID 0000-0002-9782-0819Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Charlie J. PyleiD· 2 shared David M. TobiniD· 2 shared Alwyn M. V. EckeriD· 1 shared Ana M. Xet-MulliD· 1 shared Catherine M. SteiniD· 1 shared Clare M. SmithiD· 1 shared Dennis C. KoiD· 1 shared Devjanee Swain-LenziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Charlie J. PyleORCID

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2 papers

Recent·Most cited

Granuloma Dual RNA-Seq Reveals Composite Transcriptional Programs Driven by Neutrophils and Necrosis within Tuberculous Granulomas

Gopinath Viswanathan, Erika J. Hughes, Mingyu Gan, Ana M. Xet-Mull, Jacob P Lowy, Charlie J. Pyle, Graham C Alexander, Devjanee Swain-Lenz, Qingyun Liu, David M. Tobin

The paper uses dual RNA-seq in zebrafish to study transcriptional programs in tuberculous granulomas, finding neutrophils and necrosis drive bacterial survival and adaptation.

Science Advances · Jan 21, 2026Peer-reviewedImmunology

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity

Rachel K. Meade, Oyindamola O. Adefisayo, Marco Túlio Pardini Gontijo, Summer J. Harris, Charlie J. Pyle, Kaley M. Wilburn, Alwyn M. V. Ecker, Erika J. Hughes, Paloma D. Garcia, Josh Ivie, Michael L. McHenry, Penelope H. Benchek, Harriet Mayanja‐Kizza, Jadee Neff, Dennis C. Ko, , Clare M. Smith

This study identifies cathepsin Z as a susceptibility factor for tuberculosis severity in both mice and humans, showing its role in disease outcomes through genetic and cellular analyses.

PLoS Biology · Sep 9, 2025Peer-reviewedGenetics