Jörg Tost

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

This study shows that paclitaxel resistance in triple-negative breast cancer is linked to DNA methylation changes, which can be partially reversed by decitabine to enhance chemosensitivity.

This study investigates drought-induced epigenetic memory in poplar trees, showing persistent molecular changes and distinct adaptive strategies between genotypes.

The paper compares imputation methods for targeted DNA methylation sequencing data in poplar and oak, finding NIPALS, MissForest, and LOESS as the most accurate.

The paper investigates how temperature during somatic embryo maturation in maritime pine affects DNA methylation patterns and whether these changes are mitotically transmitted to post-embryonic development.

The paper examines epigenetic responses to drought stress in two oak species, finding species-specific patterns linked to ecological preferences and potential adaptation mechanisms.

This study uses tunable DNMT1 degradation to investigate DNA methylation dynamics and genome organization, revealing cooperative roles of DNMT1 and DNMT3B and their impact on heterochromatin and cell fitness.

The paper develops HDMAX2, a method for high-dimensional mediation analysis, and applies it to study the indirect effects of maternal smoking on birth outcomes via placental DNA methylation.

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

The paper evaluates and re-annotates DNA methylation probes from two microarrays for use in two nonhuman primate species, identifying reliable probes for high-throughput methylation analysis.

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.