Author

Richard Obexer

University of ManchesterORCID 0000-0002-4940-3543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein sequence· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander T. HilditchiD· 2 shared Andrey V. RomanyukiD· 2 shared Derek N. WoolfsoniD· 2 shared Jennifer J. McManusiD· 2 shared Christopher R. Neal· 1 shared Judith MantelliD· 1 shared Lorna R. HodgsoniD· 1 shared Louise C. SerpelliD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersSynthetic Biology

Alexander T. HilditchORCID

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2 papers

Recent·Most cited

Maturation and conformational switching of a de novo designed phase-separating polypeptide

Alexander T. Hilditch, Andrey V. Romanyuk, Lorna R. Hodgson, Judith Mantell, Christopher R. Neal, Paul Verkade, Richard Obexer, Louise C. Serpell, Jennifer J. McManus, Derek N. Woolfson

This study describes a de novo designed polypeptide that forms phase-separated droplets and fibers, showing droplet maturation into β-conformations similar to pathological assemblies.

Journal of the American Chemical Society · Apr 5, 2024Peer-reviewedSynthetic Biology

Assembling membraneless organelles from de novo designed proteins

Alexander T. Hilditch, Andrey V. Romanyuk, Stephen Cross, Richard Obexer, Jennifer J. McManus, Derek N. Woolfson

The paper designs genetically encoded polypeptides that form membraneless organelles in E. coli and use them to co-compartmentalise a functional enzyme pair.

Nature Chemistry · Sep 14, 2023Peer-reviewedSynthetic Biology