Author

Olivier Le Tonquèze

University of California, San FranciscoORCID 0000-0002-4943-3566Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Anne BitoniD· 2 shared David A. SiegeliD· 2 shared David J. ErleiD· 2 shared Noah ZaitleniD· 2 shared Bob B. Buchanan· 1 shared C. Datta· 1 shared Harrison NgueiD· 1 shared J. Kreuzer· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenomics

Anne BitonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintDec 7, 2021

Ribosome changes elicit non-canonical translation for chemosurvival in G0 leukemic cells

C. Datta, Samuel Spencer Truesdell, SIA. Bukhari…·Shobha Vasudevan

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

DOI 10.1101/2021.12.07.471635

humanproteomics

𝕏 PostBluesky

GenomicsG3 Genes Genomes GeneticsPeer-reviewedNov 29, 2021

Massively Parallel Analysis of Human 3' UTRs Reveals that AU-Rich Element Length and Registration Predict mRNA Destabilization

David A Siegel, Olivier Le Tonquèze, Anne Biton…·David J. Erle

The paper uses a massively parallel reporter assay to analyze 3' UTR sequences and shows that ARE length and registration affect mRNA stability and gene expression.

63 citations

humanDNA methylation

𝕏 PostBluesky

BioinformaticsbioRxivPreprintFeb 12, 2020

MPRAudit Quantifies the Fraction of Variance Described by Unknown Features in Massively Parallel Reporter Assays

David A. Siegel, Olivier Le Tonquèze, Anne Biton…·Noah Zaitlen

MPRAudit quantifies the fraction of variance explained by unknown features in MPRA data, revealing sequence variation as the main driver of outcome variability but with known categories explaining only part of the variance.

1 citation

CRISPR screenstatistical model

𝕏 PostBluesky