Author

J. Kreuzer

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

W. Haas· 4 shared R. Morris· 3 shared M. Sade-Feldman· 2 shared A. Bardia· 1 shared A. Fasano· 1 shared A. G. Edlow· 1 shared A. L. K. Gonye· 1 shared A. N. Hata· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

W. Haas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.

E. Horwitz, T. D. Dubash, A. Szabolcs, B. S. Wittner, J. Kreuzer, R. Morris, A. Bardia, B. Chirn, D. Wiley, D. Che, H. C. Russel, X. I. H. Lopez, D. B. Fox, E. Antmen, D. T. Ting, , D. A. Haber

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

bioRxiv · Feb 20, 2024 · PreprintCancer Biology

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

M. Kathiresan, S. Animesh, R. Morris, J. Kreuzer, P. Krushna, L. Shi, J. Merritt, X. Yin, C. H. Benes, N. Bardeesy, W. Haas

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

bioRxiv · May 4, 2023 · PreprintCancer Biology

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

C. Li, M. U. Syed, A. Nimbalkar, Y. Shen, C. Fraser, Z. Inde, X. Qin, J. Ouyang, J. Kreuzer, S. E. Clark, G. E. Kelley, E. Hensley, A. Oh, M. Walcott, R. Morris, , A. N. Hata

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

bioRxiv · Sep 29, 2022 · PreprintCancer Biology

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

B. P. Boribong, T. J. LaSalle, Y. C. Bartsch, F. Ellett, M. E. Loiselle, J. P. Davis, A. L. K. Gonye, S. Hajizadeh, J. Kreuzer, S. Pillai, W. Haas, A. G. Edlow, A. Fasano, G. Alter, D. Irimia, , L. M. Yonker

The paper identifies neutrophil activation and NET formation in MIS-C linked to SARS-CoV-2 immune complexes, differing from acute pediatric COVID-19.

bioRxiv · Dec 18, 2021Immunology

Ribosome changes elicit non-canonical translation for chemosurvival in G0 leukemic cells

C. Datta, Samuel Spencer Truesdell, SIA. Bukhari, Harrison Ngue, Bob B. Buchanan, Keith Q. Wu, Olivier Le Tonquèze, S. Lee, Madeleine A. Granovetter, Myriam Boukhali, J. Kreuzer, Wilhelm Haas, Shobha Vasudevan

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

bioRxiv · Dec 7, 2021 · PreprintMolecular Biology