Diana E. Libuda

High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures

This study maps high-resolution recombination events in C. elegans, revealing sex-specific crossover patterns and their relationship with chromosomal features and structures.

Genomic sequence and structural variations accumulating between laboratory lineages of wild type C. elegans

The paper quantifies genomic differences between lab-cultivated lineages of C. elegans isolates, finding SNP and indel enrichment in introns and SV enrichment in intergenic regions.

Caenorhabditis elegans form sexually dimorphic and dynamic germ granules throughout meiotic prophase I progression

The paper characterizes the sexually dimorphic and dynamic structure of germ granules in C. elegans during meiotic prophase I, identifying sex-specific localization of PGL-1, ZNFX-1, and WAGO-4.

WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis

This study identifies sex-specific roles of WAGO-1, an Argonaute protein, in C. elegans germ granule structure and gametogenesis through structural and functional analysis.

BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during C. elegans meiosis

This study shows BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathways during C. elegans meiosis, limiting intersister crossover and error-prone repair.

Sexual dimorphic regulation of recombination by the synaptonemal complex

This study investigates sex-specific roles of synaptonemal complex proteins in meiotic recombination in C. elegans, revealing differential regulation of SYP-2 and SYP-3 in oogenesis and spermatogenesis.

A CDC-42-regulated actin network is necessary for nuclear migration through constricted spaces in C. elegans

The paper identifies CDC-42 and the Arp2/3 complex as regulators of nuclear migration in C. elegans P-cells, functioning parallel to the LINC complex.

Comprehensive detection of structural variation and transposable element differences between wild type laboratory lineages of C. elegans

The paper detects structural variations and transposable element differences between lab strains of C. elegans, revealing significant genetic drift despite assumed isogenicity.

Aging and sperm signals alter DNA break formation and repair in the C. elegans germline

This study investigates how aging and sperm depletion affect DNA break formation and repair in C. elegans germlines, finding that repair defects are age-related and independent of sperm presence.

Sister chromatid repair maintains genomic integrity during meiosis in Caenorhabditis elegans

The paper demonstrates that sister chromatid repair occurs during meiosis in C. elegans, with noncrossovers being the predominant recombination outcome and specific proteins required at different stages.

Synaptonemal complex proteins direct and constrain the localization of crossover-promoting proteins during Caenorhabditis elegans meiosis

The paper investigates how SYP proteins regulate crossover-promoting proteins during meiosis in C. elegans, showing they direct and constrain their localization to ensure proper CO formation between homologous chromosomes.