Hongtao Yu

STARNet infers gene regulatory networks from spatial multi-omics data, revealing domain-specific regulatory interactions in tissues.

The paper reveals a safety latch mechanism in the DNA-unbound MCM2-7 complex that blocks DNA entry and can be disrupted by mutations, leading to replication defects and DNA damage.

The paper shows PAX6 expression occurs post-replicatively during neuroectoderm differentiation, coupling NPC fate to cell cycle progression after DNA replication.

This study shows that CTCF orientation and R-loops regulate cohesin-mediated DNA looping and 3D genome structure.

This study shows TP53 promotes neural lineage commitment in hESCs by regulating ciliogenesis and Shh signaling through BBS9.

This study shows that STAG2-cohesin promotes myelination by generating promoter-anchored loops at myelination genes in oligodendrocytes, linking cohesin dysfunction to myelination defects in cohesinopathy.

This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.