Author

Eric Jeffrey Sherman

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-4960-4783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

James A. FaginiD· 2 shared Aasiya Islam· 1 shared Ahmet DoǧaniD· 1 shared Alan Loh HoiD· 1 shared Andrew T. AukermaniD· 1 shared Angela Rose BrannoniD· 1 shared Anika Begum· 1 shared Areej AlsaafiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

James A. FaginORCID

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2 papers

Recent·Most cited

Loss of tumor cell MHC Class II drives insensitivity of BRAF-mutant anaplastic thyroid cancers to MAPK inhibitors

Vera Tiedje, Jillian Greenberg, Tianyue Qin, Soo-Yeon Im, Gnana Prakasam Krishnamoorthy, Laura Boucai, Bin Xu, Jena D. French, Eric Jeffrey Sherman, Alan Loh Ho, Elisa de Stanchina, Nicholas D. Socci, Jian Jun Jin, Ronald A. Ghossein, Jeffrey A. Knauf, , James A. Fagin

This study shows that loss of MHC Class II in BRAF-mutant anaplastic thyroid cancers leads to resistance to MAPK inhibitors by reducing CD4+ T-cell activation.

Journal of Clinical Investigation · Aug 19, 2025Peer-reviewedCancer Biology

Integrated histopathologic modeling of detailed tumor subtypes and actionable biomarkers

Kevin M Boehm, Madison Darmofal, Arfath Pasha, Andrew T. Aukerman, Raymond S. Lim, Evan Seffar, Tom Pollard, Natasha Rekhtman, Jason C. Chang, Armaan Kohli, Darin Moore, Marta Ligero, Jianjiong Gao, Georgios Asimomitis, Anika Begum, , Francisco Sánchez-Vega

The paper develops Mosaic, a machine learning system that classifies tumors into detailed subtypes and identifies molecular phenotypes using histopathologic and genomic data from a large patient cohort.

bioRxiv · Aug 14, 2025 · PreprintCancer Biology