Alberto Granzotto

The paper investigates off-target interactions of amyloid PET tracers with brain sulfotransferases using multi-omic and computational methods, revealing enzyme-specific binding dynamics and implications for PET signal variability.

This study shows that the amyloid PET tracer PiB interacts with acetylcholinesterase, potentially affecting PET signal interpretation in Alzheimer's disease.

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

The paper investigates how NMDA receptors in nNOS (+) neurons change over time after excitotoxic stress, revealing redox-driven adaptations that reduce neuronal vulnerability.

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.

This study shows that inhibiting de novo ceramide biosynthesis with L-cycloserine improves aging-related phenotypes in cultured cortical neurons.

This study shows that reducing brain zinc levels with clioquinol impairs memory and BDNF-related signaling in young mice.

This study shows exenatide improves BDNF signaling and reduces neuroinflammation in 3xTg-AD mice on a high-fat diet.