Samrat Chatterjee

Single-cell informed metabolic modeling reveals organ-specific metabolic adaptations in breast cancer organotropism

This study uses single-cell transcriptomics and metabolic modeling to identify shared and organ-specific metabolic adaptations in breast cancer metastasis to the liver, bone, and brain.

Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in Mycobacterium tuberculosis

This study shows that limiting sulfur availability in Mycobacterium tuberculosis increases its vulnerability to antibiotics and enhances drug efficacy in a mouse model.

CircDiscoverer: A multispecies comprehensive resource for circRNA-protein interactions and RNA modification landscapes

CircDiscoverer provides a resource for exploring circRNA-protein interactions and RNA modifications across multiple species.

Network controllability analysis reveals the antiviral potential of Etravirine against Hepatitis E Virus infection

This study identifies CK1ε as an antiviral target for HEV and shows that Etravirine, an HIV drug, inhibits CK1ε to exhibit antiviral activity against HEV.

Phosphoglucomutase A mediated regulation of carbon flux is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

Targeting metabolic fluxes reverts metastatic transitions in ovarian cancer

The paper identifies metabolic reaction modules driving metastatic transitions in ovarian cancer and validates oseltamivir as a non-cytotoxic drug to disrupt spheroidal morphologies.

BAG6 is a novel player in controlling nonalcoholic steatohepatitis: result from a comprehensive in-silico study

This study identifies BAG6 as a novel target for NASH using in-silico methods, showing its role in reducing fatty acid accumulation and NASH-signature transcripts in Huh-7 cells.