Manitosh Pandey

Orthogonal perturbation of sulfur availability reveals antibiotic-induced synthetic lethality in Mycobacterium tuberculosis

This study shows that limiting sulfur availability in Mycobacterium tuberculosis increases its vulnerability to antibiotics and enhances drug efficacy in a mouse model.

Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus

The paper shows that Mycobacterium abscessus grows preferentially in granulomas formed by prior Mycobacterium marinum infection in zebrafish, exploiting a nutrient-rich niche.

GplR1, an unusual TetR-like transcription factor in Mycobacterium abscessus, controls the production of cell wall glycopeptidolipids, colony morphology, and virulence

This paper identifies GplR1, a transcription factor in Mycobacterium abscessus, as a regulator of glycopeptidolipid production, colony morphology, and virulence.

Phosphoglucomutase A mediated regulation of carbon flux is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

Telomerase reverse transcriptase is required for resistance to mycobacterial infection

This study shows that telomerase reverse transcriptase (Tert) is essential for resistance to mycobacterial infection by supporting demand-driven hematopoiesis in zebrafish.

pH dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis

This study shows that the direct sulfhydrylation pathway in Mycobacterium tuberculosis is essential for growth at low pH and modulates BDQ sensitivity.